The simple answer is “yes.”
However, you will need to confirm with your local jurisdiction as to which version of ADA or state disability code is being applied to determine the size permitted.
The 2010 ADA Standards for Accessible Design clearly states that handrail is to be between 1-1/4 and 2″ in diameter.
We have Lumenrail available in 1-1/2, 1.66, 1.90 and 2-inch diameters so we have the full range covered.